Institute of Cell Biology National Academy of Sciences of Ukraine
Department of Regulation of Cell Proliferation and Apoptosis
The main research topics:
molecular mechanisms of regulation of proliferation and apoptosis of tumor and immune cells of mammalians;
search for and identification of novel bio-markers of apoptosis at antitumor chemotherapy;
detection, isolation and biochemical characterization of novel abzymes (catalytically active antibodies) in blood serum of patients with autoimmune diseases, cancer, and in human milk;
detection, isolation and characterization of novel protein and peptide triggers in pathogenesis of autoimmune and oncological diseases;
role of immunogenic cell death in cancer suppression;
search for novel natural (plants and higher mushrooms) low molecular substances (alkaloids and tri-terpens) possessing anticancer and immunomodulating activities;
bio-evaluation of novel nanoscale materials (mineral and polymeric) with conjugated functional bio-elements (specific lectin or immunoglobulin) and label (fluorescent dye or super-paramagnetic core) (developed in collaboration with the Department of Organic Chemistry of National University "Lviv Polytechnica" and other research partner institutions);
the application of nanoscale polymeric materials for drug and gene delivery;
isolation of chitosan and preparation of its low molecular weight derivatives; the use of these derivatives for drug and gene delivery;
cellular and molecular mechanisms of anticancer action of novel antibiotics of landomycin family;
cellular and molecular mechanisms of anticancer action of novel derivatives of berberine alkaloid (developed in collaboration with Institute of Biology, Shendong Academy of Sciences, China);
cellular and molecular mechanisms of anticancer action of novel 4-thiazolidinone derivatives (developed in collaboration with Danylo Halytsky Lviv National Medical University);
cellular and molecular mechanisms of anticancer action of novel thiazol derivatives (developed in collaboration with Ivan Franko Lviv National University).
